In order to develop this fundamental understanding for processing defects with LPBF, it is necessary to generate representative defects in a controlled manner to enable quantitative studies of the mechanical property debits and probability of detection (PoD) of authentic LPBF defects. The technical approach and methodology include over a dozen LPBF build iterations in IN718, model-informed analysis of local processing conditions, in-situ process monitoring, post build computed tomography (CT), mechanical testing (fatigue), and user developed LPBF fusion machine control. Combining process modeling with in-situ monitoring accelerates determination of the key process parameters needed to control the formation and severity of typically observed LPBF defect types. CT and mechanical testing are being used to verify the presence of morphologically representative defects, as well as benchmark their mechanical performance debits relative to legacy data. Ohio State University (OSU) has demonstrated its ability to control numerous key processing parameters to achieve desired material response (high density) in the ongoing America Makes project #3014. The scope of this program acts as a continuation to elicit the opposite result in otherwise quality material. To ensure transition to America Makes and the DoD supply chain, OSU is partnering with a local small business AM supplier, Proto Precision Additive, and large aerospace and defense OEM/ Propulsion Supplier Rolls-Royce and Lockheed Martin.